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pAbnormalities in laboratory tests may occur during therapy with Danazol including CPKglucose toleranceglucagonthyroid binding globulinsex hormone binding globulinother plasma proteinslipids and lipoproteins./ppA temporary alteration of lipoproteins in the form of decreased high density lipoproteins and possibly increased low density lipoproteins has been reported during Danazol therapyThese alterations may be markedand prescribers should consider the potential impact on the risk of atherosclerosis and coronary artery disease in accordance with the potential benefit of the therapy to the patient./ppDanazol is an effective treatment for endometriosisand has the same effectiveness as the other hormonal treatmentsHoweverit has many androgenicmale-likeside effectsincluding weight gainincreased body hair and acneIts unpleasant side effects and its tendency to adversely affect blood lipidcholesterollevels mean it is not usually the first choice of treatment for endometriosis1/ppYou should start your course of danazol on the first day of your period to decrease the risk of taking the drug while you are pregnantIf there is any possibility that you may be pregnantyou should have a pregnancy test before starting treatment4/p

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danazol could inhibit progesterone and 17alpha-hydroxy-progesterone binding to microsomal p-450 1 .