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Symptoms of colchicine toxicity include gastrointestinal upset, fever, myalgia, pancytopenia, and organ failure.
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pCo-administration of colchicine capsules with propafenonea P-gp inhibitorat 225 mg BID for 5 daysin a pharmacokinetic study in healthy volunteersdid not cause any changes in systemic levels of colchicineThis indicates that propafenone can be administered with colchicine capsules without any dose adjustmentHoweverthese results should not be extrapolated to other P-gp inhibitors as colchicine is known to be a substrate for P-gp and case reports of colchicine toxicity associated with the co-administration of P-gp inhibitors such as cyclosporine have been published./ppRead the Medication Guide provided by your pharmacist before you start taking colchicine and each time you get a refillIf you have any questions regarding the informationask your doctor or pharmacist./ppA 4-fold reduction in colchicine dosage is recommended when co-administered with a P-gp inhibitor and/or a strong CYP3A4 inhibitorA 2-fold reduction in colchicine dosage is recommended when co-administered with a moderate CYP3A4 inhibitor./p
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