Cefixime is a semisynthetic cephalosporin antibiotic.
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pAllergic reactionssuperinfectionrenal dysfunctiontoxic nephropathyhepatic dysfunction including cholestasisaplastic anemiahemolytic anemiahemorrhageand colitis./ppElevated carbamazepine levels have been reported in postmarketing experience when cefixime is administered concomitantlyDrug monitoring may be of assistance in detecting alterations in carbamazepine plasma concentrations./ppCefiximean antibioticis a third-generation cephalosporin like ceftriaxone and cefotaximeCefixime is highly stable in the presence of beta-lactamase enzymesAs a resultmany organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamasesmay be susceptible to cefiximeThe antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall./p
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however, clinical trials done in the late 1980s and early 1990s found that a single dose of 800 mg cefixime was well tolerated.